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IGF-1 DES

Catalog No. A6017
Size Price Stock Qty
1mg
$35.00
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IGF-1 DES

Quality Control & MSDS

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Properties

Cas No. N/A
Chemical Name IGF-1 DES
Formula C319H501N91O96S7
One Letter Sequence TLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPAKSA
Three Letter Sequence H-Thr-Leu-Cys-Gly-Ala-Glu-Leu-Val-Asp-Ala-Leu-Gln-Phe-Val-Cys-Gly-Asp-Arg-Gly-Phe-Tyr-Phe-Asn-Lys-Pro-Thr-Gly-Tyr-Gly-Ser-Ser-Ser-Arg-Arg-Ala-Pro-Gln-Thr-Gly-Ile-Val-Asp-Glu-Cys-Cys-Phe-Arg-Ser-Cys-Asp-Leu-Arg-Arg-Leu-Glu-Met-Tyr-Cys-Ala-Pro-Leu-Lys-Pro-A
Molecular Weight (MW) 7371.4
Solubility aqueous soluble
Storage Lyophilized IGF-1 DES although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution FST should be stored at 4°C between 2-7 days and for future use below -18°C.

Overview

IGF Insulin Like Growth Factor (IGF)-1 (4-70), also named DES-(l-3)-insulin-like growth factor-l (IGF-1 DES), is a non-glycosylated, polypeptide chain containing 67 amino acids.

IGF-1 DES is a brain specific form of IGF-1. It has influence on survival, morphological growth and transmitter-specific differentiation of  dopaminergic neurons of rats.  IGF-1 DES was  found  to  differentially  regulate  development  of  dopaminergic  cells.  IGF-1 DES  was  most  effective  in  promoting  survival,  stimulated  dopamine  uptake, less effectively  than  brain-derived  neurotrophic  factor  and  did  not  alter  the  morphology  of  dopaminergic  cells. Basic  fibroblast  growth  factor  produced  comparatively  mild  increases  in  survival  and  dopamine  uptake, and  slightly  reduced  neurite  growth  of  the  cells.  None  of  the  factors  stimulated  the  expression  of  the tyrosine  hydroxylase  gene [1].

It has been reported that IGF-1 DES is ten times more potent than IGF-1 at stimulating hypertrophy and proliferation in cultured cells. It is likely generated through post-translational modification in the sequence of circulating mature IGF-1 via protease action. IGF1 mediates many of the growth-promoting effects of growth hormone and IGF-1 DES, although shorter, pacts an equal amount of physiological altering protein physical changes.

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A6017_2

References:

1. Beck KD1, Knüsel B, Hefti F. The nature of the trophic action of brain-derived neurotrophic factor, des(1-3)-insulin-like growth factor-1, and basic fibroblast growth factor on mesencephalic dopaminergic neurons developing in culture. Neuroscience. 1993 Feb;52(4):855-66.