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IGF-1 DES

Catalog No. A6017
Size Price Stock Qty
1mg
$35.00
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IGF-1 DES

Quality Control & MSDS

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Properties

Cas No. N/A
Chemical Name IGF-1 DES
Formula C319H501N91O96S7
One Letter Sequence TLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPAKSA
Three Letter Sequence H-Thr-Leu-Cys-Gly-Ala-Glu-Leu-Val-Asp-Ala-Leu-Gln-Phe-Val-Cys-Gly-Asp-Arg-Gly-Phe-Tyr-Phe-Asn-Lys-Pro-Thr-Gly-Tyr-Gly-Ser-Ser-Ser-Arg-Arg-Ala-Pro-Gln-Thr-Gly-Ile-Val-Asp-Glu-Cys-Cys-Phe-Arg-Ser-Cys-Asp-Leu-Arg-Arg-Leu-Glu-Met-Tyr-Cys-Ala-Pro-Leu-Lys-Pro-A
Molecular Weight (MW) 7371.4
Solubility aqueous soluble
Storage Lyophilized IGF-1 DES although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution FST should be stored at 4°C between 2-7 days and for future use below -18°C.

Overview

IGF-1 DES is a truncated analogue of IGF-1 [1].

IGF-1 DES is a truncated form of human IGF-1with the tripeptide Gly-Pro-Glu absent from the N-terminus. It can stimulate the protein and DNA synthesis and inhibit protein breakdown with higher potency than IGF-1, results from an increased free peptide being available for interaction with cell receptors. The IC50 values of IGF-1 DES to inhibit protein breakdown are 0.02nM, 0.02nM and 0.15nM, respectively in L6 myoblasts, HE (39) L fibroblasts and chick embryo fibroblasts. Besides that, IGF-1 DES is also found to have activity to enhance growth in rats after partial gut resection. The effects of 2.4mg/kg per day IGF-1 is similar to IGF-1 DES at 40% dose of IGF-1. IGF-1 DES significantly produces weight gains and improves nitrogen balances relative to the controls [2, 3].

[1] John Ballard F, Wallace J C, Francis G L, et al. Des (1–3) IGF-I: a truncated form of insulin-like growth factor-I. The international journal of biochemistry & cell biology, 1996, 28(10): 1085-1087.

[2] Ross M, Francis G L, Szabo L, et al. Insulin-like growth factor (IGF)-binding proteins inhibit the biological activities of IGF-1 and IGF-2 but not des-(1-3)-IGF-1. Biochem. J, 1989, 258: 267-272.

[3] Lemmey A B, Martin A A, Read L C, et al. IGF-I and the truncated analogue des-(1-3) IGF-I enhance growth in rats after gut resection. Am J Physiol, 1991, 260(2 Pt 1): E213-9.