Quality Control & MSDS
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|Chemical Name||IGF-1 DES|
|One Letter Sequence||TLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPAKSA|
|Three Letter Sequence||H-Thr-Leu-Cys-Gly-Ala-Glu-Leu-Val-Asp-Ala-Leu-Gln-Phe-Val-Cys-Gly-Asp-Arg-Gly-Phe-Tyr-Phe-Asn-Lys-Pro-Thr-Gly-Tyr-Gly-Ser-Ser-Ser-Arg-Arg-Ala-Pro-Gln-Thr-Gly-Ile-Val-Asp-Glu-Cys-Cys-Phe-Arg-Ser-Cys-Asp-Leu-Arg-Arg-Leu-Glu-Met-Tyr-Cys-Ala-Pro-Leu-Lys-Pro-A|
|Molecular Weight (MW)||7371.4|
|Storage||Lyophilized IGF-1 DES although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution FST should be stored at 4°C between 2-7 days and for future use below -18°C.|
IGF Insulin Like Growth Factor (IGF)-1 (4-70), also named DES-(l-3)-insulin-like growth factor-l (IGF-1 DES), is a non-glycosylated, polypeptide chain containing 67 amino acids.
IGF-1 DES is a brain specific form of IGF-1. It has influence on survival, morphological growth and transmitter-specific differentiation of dopaminergic neurons of rats. IGF-1 DES was found to differentially regulate development of dopaminergic cells. IGF-1 DES was most effective in promoting survival, stimulated dopamine uptake, less effectively than brain-derived neurotrophic factor and did not alter the morphology of dopaminergic cells. Basic fibroblast growth factor produced comparatively mild increases in survival and dopamine uptake, and slightly reduced neurite growth of the cells. None of the factors stimulated the expression of the tyrosine hydroxylase gene .
It has been reported that IGF-1 DES is ten times more potent than IGF-1 at stimulating hypertrophy and proliferation in cultured cells. It is likely generated through post-translational modification in the sequence of circulating mature IGF-1 via protease action. IGF1 mediates many of the growth-promoting effects of growth hormone and IGF-1 DES, although shorter, pacts an equal amount of physiological altering protein physical changes.
1. Beck KD1, Knüsel B, Hefti F. The nature of the trophic action of brain-derived neurotrophic factor, des(1-3)-insulin-like growth factor-1, and basic fibroblast growth factor on mesencephalic dopaminergic neurons developing in culture. Neuroscience. 1993 Feb;52(4):855-66.